› 4lsg

X-ray diffraction
3.8Å resolution

Structure of Mouse P-Glycoprotein

Released:
DOI: 10.2210/pdb4lsg/pdb
PDB entry 4lsg coloured by chain, front view.
PDB entry 4lsg coloured by chain, side view.
PDB entry 4lsg coloured by chain, top view.
Source organism: Mus musculus
Entry authors: Chang G, Szewczyk P

Function and Biology Details

Reactions catalysed: 
ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2)
ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-149243 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ATP-dependent translocase ABCB1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 1284 amino acids
Theoretical weight: 141.85 KDa
Source organism: Mus musculus
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P21447 (Residues: 1-1276; Coverage: 100%)
Gene names: Abcb1a, Abcb4, Mdr1a, Mdr3, Pgy-3, Pgy3
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand HG 12 x HG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P212121
Unit cell:
a: 97.542Å b: 115.426Å c: 378.858Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.338 0.336 0.357
Expression system: Komagataella pastoris

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