› 4lt7

X-ray diffraction
2.5Å resolution

Crystal structure of the c2a domain of rabphilin-3a in complex with a calcium

Released:
DOI: 10.2210/pdb4lt7/pdb
Model geometry
Fit model/data
PDB entry 4lt7 coloured by chain, front view.
PDB entry 4lt7 coloured by chain, side view.
PDB entry 4lt7 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural insights into the Ca2+ and PI(4,5)P2 binding modes of the C2 domains of rabphilin 3A and synaptotagmin 1.
Guillén J, Ferrer-Orta C, Buxaderas M, Pérez-Sánchez D, Guerrero-Valero M, Luengo-Gil G, Pous J, Guerra P, Gómez-Fernández JC, Verdaguer N, Corbalán-García S
Proc Natl Acad Sci U S A 110 20503-8 (2013)
PMID: 24302762

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155637 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Rabphilin-3A Chain: A
Molecule details ›
Chain: A
Length: 133 amino acids
Theoretical weight: 15.31 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P47709 (Residues: 378-510; Coverage: 19%)
Gene name: Rph3a
Sequence domains: C2 domain
Structure domains: C2 domain

Ligands and Environments

1 bound ligand:
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P212121
Unit cell:
a: 38.69Å b: 40.03Å c: 90.25Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.245 0.243 0.289
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

10 review citations

Signaling through C2 domains: more than one lipid target.
Corbalan-Garcia et al. (2014)
9 more

1 mention without citation

Structural insights into the Ca2+ and PI(4,5)P2 binding modes of the C2 domains of rabphilin 3A and synaptotagmin 1.
Guillén et al. (2013)