› 4lvv

X-ray diffraction
2.1Å resolution

Structure of the THF riboswitch

Released:
DOI: 10.2210/pdb4lvv/pdb
PDB entry 4lvv coloured by chain, front view.
PDB entry 4lvv coloured by chain, side view.
PDB entry 4lvv coloured by chain, top view.
Source organism: Streptococcus mutans
Primary publication:
A disconnect between high-affinity binding and efficient regulation by antifolates and purines in the tetrahydrofolate riboswitch.
Trausch JJ, Batey RT
Chem Biol 21 205-16 (2014)
PMID: 24388757

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195914 (preferred)
Entry contents:
1 distinct RNA molecule
Macromolecule:
THF riboswitch Chain: A
Molecule details ›
Chain: A
Length: 89 nucleotides
Theoretical weight: 28.85 KDa
Source organism: Streptococcus mutans
Expression system: Not provided
Sequence domains: THF riboswitch

Ligands and Environments

1 bound ligand:
Ligand FFO 2 x FFO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P212121
Unit cell:
a: 27.81Å b: 67.41Å c: 156.68Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.203 0.227
Expression system: Not provided

Quick links

Citations

6 review citations

RNA aptamers as genetic control devices: the potential of riboswitches as synthetic elements for regulating gene expression.
Berens et al. (2015)
5 more

18 mentions without citation

Long-Range Interactions in Riboswitch Control of Gene Expression.
Jones et al. (2017)
17 more