4lx2

X-ray diffraction
1.5Å resolution

Crystal structure of Myo5a globular tail domain in complex with melanophilin GTBD

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-187559 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Unconventional myosin-Va Chain: A
Molecule details ›
Chain: A
Length: 392 amino acids
Theoretical weight: 44.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y4I1 (Residues: 1464-1855; Coverage: 21%)
Gene names: MYH12, MYO5A
Sequence domains: DIL domain
Melanophilin Chain: B
Molecule details ›
Chain: B
Length: 26 amino acids
Theoretical weight: 3.17 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: Q91V27 (Residues: 176-201; Coverage: 4%)
Gene names: Ln, Mlph, Slac2a

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: C2
Unit cell:
a: 99.87Å b: 41.11Å c: 109.58Å
α: 90° β: 115.63° γ: 90°
R-values:
R R work R free
0.166 0.164 0.196
Expression systems:
  • Escherichia coli
  • Not provided