› 4lz6

X-ray diffraction
3.2Å resolution

Structure of MATE multidrug transporter DinF-BH

Released:
DOI: 10.2210/pdb4lz6/pdb
PDB entry 4lz6 coloured by chain, front view.
PDB entry 4lz6 coloured by chain, side view.
PDB entry 4lz6 coloured by chain, top view.
Source organism: Alkalihalobacillus halodurans C-125
Primary publication:
Structural insights into H+-coupled multidrug extrusion by a MATE transporter.
Lu M, Radchenko M, Symersky J, Nie R, Guo Y
Nat Struct Mol Biol 20 1310-7 (2013)
PMID: 24141706

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-191815 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Multidrug export protein MepA Chain: A
Molecule details ›
Chain: A
Length: 446 amino acids
Theoretical weight: 48.62 KDa
Source organism: Alkalihalobacillus halodurans C-125
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9KAX3 (Residues: 3-448; Coverage: 96%)
Gene name: BH2163
Sequence domains: MatE

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P212121
Unit cell:
a: 90.759Å b: 95.073Å c: 101.652Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.3 0.29 0.31
Expression system: Escherichia coli

Quick links

Citations

16 review citations

Multidrug efflux pumps: structure, function and regulation.
Du et al. (2018)
15 more

11 mentions without citation

Structural Insights into Transporter-Mediated Drug Resistance in Infectious Diseases.
Kim et al. (2021)
10 more