› 4m1m

X-ray diffraction
3.8Å resolution

Corrected Structure of Mouse P-glycoprotein

Released:
DOI: 10.2210/pdb4m1m/pdb
PDB entry 4m1m coloured by chain, front view.
PDB entry 4m1m coloured by chain, side view.
PDB entry 4m1m coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Refined structures of mouse P-glycoprotein.
Li J, Jaimes KF, Aller SG
Protein Sci 23 34-46 (2014)
PMID: 24155053

Function and Biology Details

Reactions catalysed: 
ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2)
ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149243 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ATP-dependent translocase ABCB1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 1282 amino acids
Theoretical weight: 141.65 KDa
Source organism: Mus musculus
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P21447 (Residues: 1-1276; Coverage: 100%)
Gene names: Abcb1a, Abcb4, Mdr1a, Mdr3, Pgy-3, Pgy3
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand HG 13 x HG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P212121
Unit cell:
a: 97.544Å b: 115.426Å c: 378.858Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.212 0.266
Expression system: Komagataella pastoris

Quick links

Citations

32 review citations

Mechanistic diversity in ATP-binding cassette (ABC) transporters.
Locher KP. (2016)
31 more

77 mentions without citation

Structural diversity of ABC transporters.
ter Beek et al. (2014)
76 more