Function and Biology Details
Reactions catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
DNA polymerase beta and DNA (preferred)
PDBe Complex ID:
PDB-CPX-117829 (preferred)
Entry contents:
1 distinct polypeptide molecule
3 distinct DNA molecules
3 distinct DNA molecules
Macromolecules (4 distinct):
DNA polymerase beta
Molecule details ›
Chain: A
Length: 324 amino acids
Theoretical weight: 36.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 324 amino acids
Theoretical weight: 36.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P06746 (Residues: 12-335; Coverage: 97%)
Sequence domains:
- Helix-hairpin-helix domain
- Fingers domain of DNA polymerase lambda
- DNA polymerase beta palm
- DNA polymerase beta thumb
