› 4m6e

X-ray diffraction
0.95Å resolution

The high resolution structure of tyrocidine A reveals an amphipathic dimer

Released:
DOI: 10.2210/pdb4m6e/pdb
PDB entry 4m6e coloured by chain, front view.
PDB entry 4m6e coloured by chain, side view.
PDB entry 4m6e coloured by chain, top view.
Source organism: Brevibacillus brevis
Primary publication:
The high resolution structure of tyrocidine A reveals an amphipathic dimer.
Loll PJ, Upton EC, Nahoum V, Economou NJ, Cocklin S
Biochim Biophys Acta 1838 1199-207 (2014)
PMID: 24530898

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-164802 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
tyrocidine A Chain: A
Molecule details ›
Chain: A
Length: 10 amino acids
Theoretical weight: 1.29 KDa
Source organism: Brevibacillus brevis

Ligands and Environments

2 bound ligands:
Ligand MPD 1 x MPD
Ligand MOH 3 x MOH
2 modified residues:
Ligand DPN 2 x DPN
Ligand ORN 1 x ORN

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X6A
Spacegroup: R32
Unit cell:
a: 33.39Å b: 33.39Å c: 50.57Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.135 0.134 0.142

Quick links

Citations

2 review citations

Roles of d-Amino Acids on the Bioactivity of Host Defense Peptides.
Li et al. (2016)
1 more

2 mentions without citation

Structure-Function Characteristics of SARS-CoV-2 Proteases and Their Potential Inhibitors from Microbial Sources.
Razali et al. (2021)
1 more