› 4m7h

X-ray diffraction
2Å resolution

Crystal structure of tetrameric fibrinogen-like recognition domain of FIBCD1

Released:
DOI: 10.2210/pdb4m7h/pdb
PDB entry 4m7h coloured by chain, front view.
PDB entry 4m7h coloured by chain, side view.
PDB entry 4m7h coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the tetrameric fibrinogen-like recognition domain of fibrinogen C domain containing 1 (FIBCD1) protein.
Shrive AK, Moeller JB, Burns I, Paterson JM, Shaw AJ, Schlosser A, Sorensen GL, Greenhough TJ, Holmskov U
J Biol Chem 289 2880-7 (2014)
PMID: 24293368

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185399 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibrinogen C domain-containing protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 226 amino acids
Theoretical weight: 25.69 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8N539 (Residues: 236-461; Coverage: 49%)
Gene names: FIBCD1, UNQ701/PRO1346
Sequence domains: Fibrinogen beta and gamma chains, C-terminal globular domain
Structure domains:

Ligands and Environments

5 bound ligands:
Ligand CA 2 x CA
Ligand NAG 1 x NAG
Ligand ACY 1 x ACY
Ligand SO4 3 x SO4
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.1
Spacegroup: P4
Unit cell:
a: 118.56Å b: 118.56Å c: 44.25Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.183 0.209
Expression system: Spodoptera frugiperda

Quick links

Citations

2 review citations

Infectious Agents as Stimuli of Trained Innate Immunity.
Rusek et al. (2018)
1 more

2 mentions without citation

Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers.
Zuliani-Alvarez et al. (2017)
1 more