› 4mgp

X-ray diffraction
1.75Å resolution

Structure of racemic Ala-(8,13,18) Magainin 2

Released:
DOI: 10.2210/pdb4mgp/pdb
PDB entry 4mgp coloured by chain, front view.
PDB entry 4mgp coloured by chain, side view.
PDB entry 4mgp coloured by chain, top view.
Source organism: Xenopus laevis
Primary publication:
Evidence for phenylalanine zipper-mediated dimerization in the X-ray crystal structure of a magainin 2 analogue.
Hayouka Z, Mortenson DE, Kreitler DF, Weisblum B, Forest KT, Gellman SH
J Am Chem Soc 135 15738-15741 (2013)
PMID: 24102563

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145626 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Magainin-2 Chain: A
Molecule details ›
Chain: A
Length: 23 amino acids
Theoretical weight: 2.48 KDa
Source organism: Xenopus laevis
Expression system: Not provided
UniProt:
  • Canonical: P11006 (Residues: 267-289; Coverage: 8%)
Gene name: magainins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: I-42d
Unit cell:
a: 53.38Å b: 53.459Å c: 29.75Å
α: 89.97° β: 90.07° γ: 89.98°
R-values:
R R work R free
0.198 0.196 0.233
Expression system: Not provided

Quick links

Citations

2 review citations

The Human Antimicrobial Peptides Dermcidin and LL-37 Show Novel Distinct Pathways in Membrane Interactions.
Zeth et al. (2017)
1 more

4 mentions without citation

Evidence for phenylalanine zipper-mediated dimerization in the X-ray crystal structure of a magainin 2 analogue.
Hayouka et al. (2013)
3 more