› 4mhe

X-ray diffraction
2.1Å resolution

Crystal structure of CC-chemokine 18

Released:
DOI: 10.2210/pdb4mhe/pdb
PDB entry 4mhe coloured by chain, front view.
PDB entry 4mhe coloured by chain, side view.
PDB entry 4mhe coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme.
Liang WG, Ren M, Zhao F, Tang WJ
J Mol Biol 427 1345-1358 (2015)
PMID: 25636406

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157312 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-C motif chemokine 18 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 70 amino acids
Theoretical weight: 7.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P55774 (Residues: 21-89; Coverage: 100%)
Gene names: AMAC1, CCL18, DCCK1, MIP4, PARC, SCYA18
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

1 bound ligand:
Ligand ACT 1 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21
Unit cell:
a: 52.075Å b: 55.168Å c: 60.377Å
α: 90° β: 109.25° γ: 90°
R-values:
R R work R free
0.18 0.176 0.218
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Hepatic Insulin Clearance: Mechanism and Physiology.
Najjar et al. (2019)
6 more

5 mentions without citation

CCL18 in the Progression of Cancer.
Korbecki et al. (2020)
4 more