4mi8

X-ray diffraction
2.1Å resolution

Crystal structure of the complex of murine gamma-herpesvirus 68 Bcl-2 homolog M11 and a Beclin 1 BH3 domain-derived peptide

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero octamer
PDBe Complex ID:
PDB-CPX-161027 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Apoptosis regulator Bcl-2 homolog Chains: A, B
Molecule details ›
Chains: A, B
Length: 143 amino acids
Theoretical weight: 16.65 KDa
Source organism: Murid gammaherpesvirus 4
Expression system: Escherichia coli
UniProt:
  • Canonical: P89884 (Residues: 2-136; Coverage: 79%)
Gene name: vBCL2
Sequence domains: Apoptosis regulator M11, B cell 2 leukaemia/lymphoma like
Structure domains: Blc2-like
Beclin-1 Chains: C, D
Molecule details ›
Chains: C, D
Length: 26 amino acids
Theoretical weight: 2.85 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q14457 (Residues: 107-130; Coverage: 5%)
Gene names: BECN1, GT197
Sequence domains: Beclin-1 BH3 domain, Bcl-2-interacting

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: C2
Unit cell:
a: 70.598Å b: 140.844Å c: 54.038Å
α: 90° β: 127.81° γ: 90°
R-values:
R R work R free
0.16 0.156 0.224
Expression systems:
  • Escherichia coli
  • Not provided