› 4mt4

X-ray diffraction
2.37Å resolution

Crystal structure of the Campylobacter jejuni CmeC outer membrane channel

Released:
DOI: 10.2210/pdb4mt4/pdb
PDB entry 4mt4 coloured by chain, front view.
PDB entry 4mt4 coloured by chain, side view.
PDB entry 4mt4 coloured by chain, top view.
Source organism: Campylobacter jejuni
Primary publication:
Crystal structure of the Campylobacter jejuni CmeC outer membrane channel.
Su CC, Radhakrishnan A, Kumar N, Long F, Bolla JR, Lei HT, Delmar JA, Do SV, Chou TH, Rajashankar KR, Zhang Q, Yu EW
Protein Sci 23 954-61 (2014)
PMID: 24753291

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186042 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CmeC Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 479 amino acids
Theoretical weight: 54.31 KDa
Source organism: Campylobacter jejuni
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8RTE3 (Residues: 20-492; Coverage: 100%)
Gene name: cmeC
Sequence domains: Outer membrane efflux protein
Structure domains: Outer membrane efflux proteins (OEP)

Ligands and Environments

3 bound ligands:
Ligand C8E 18 x C8E
Ligand SO4 2 x SO4
Ligand 3PK 3 x 3PK
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: C2221
Unit cell:
a: 91.827Å b: 146.324Å c: 418.866Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.21 0.243
Expression system: Escherichia coli

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Citations

7 review citations

Structure, mechanism and cooperation of bacterial multidrug transporters.
Du et al. (2015)
6 more

12 mentions without citation

Structure, Assembly, and Function of Tripartite Efflux and Type 1 Secretion Systems in Gram-Negative Bacteria.
Alav et al. (2021)
11 more