› 4mtl

X-ray diffraction
1.65Å resolution

Human Methyltransferase-Like Protein 21C

Released:
DOI: 10.2210/pdb4mtl/pdb
PDB entry 4mtl coloured by chain, front view.
PDB entry 4mtl coloured by chain, side view.
PDB entry 4mtl coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Hong BS, Tempel W, Dong A, Li Y, Arrowsmith CH, Bountra C, Edwards AM, Brown PJ, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178457 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein-lysine methyltransferase METTL21C Chains: A, B
Molecule details ›
Chains: A, B
Length: 244 amino acids
Theoretical weight: 27.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q5VZV1 (Residues: 22-264; Coverage: 92%)
Gene names: C13orf39, METTL21C
Sequence domains: Lysine methyltransferase
Structure domains: Vaccinia Virus protein VP39

Ligands and Environments

2 bound ligands:
Ligand SAH 2 x SAH
Ligand UNX 37 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Unit cell:
a: 103.554Å b: 43.247Å c: 119.454Å
α: 90° β: 99.17° γ: 90°
R-values:
R R work R free
0.17 0.169 0.196
Expression system: Escherichia coli BL21(DE3)

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