› 4mvc

X-ray diffraction
3Å resolution

Function and Biology Details

Reaction catalysed: 
CTP + phosphocholine = diphosphate + CDP-choline
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148762 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Choline-phosphate cytidylyltransferase A Chains: A, B
Molecule details ›
Chains: A, B
Length: 300 amino acids
Theoretical weight: 34.11 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P19836 (Residues: 1-312; Coverage: 76%)
Gene names: Ctpct, Pcyt1, Pcyt1a
Sequence domains: Cytidylyltransferase-like
Structure domains: HUPs

Ligands and Environments

1 bound ligand:
Ligand CDC 2 x CDC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08B1-1
Spacegroup: P21
Unit cell:
a: 87.26Å b: 44.55Å c: 97.13Å
α: 90° β: 111.21° γ: 90°
R-values:
R R work R free
0.226 0.223 0.288
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

7 review citations

Lipid landscapes and pipelines in membrane homeostasis.
Holthuis et al. (2014)
6 more

9 mentions without citation

Genetic diseases of the Kennedy pathways for membrane synthesis.
Tavasoli et al. (2020)
8 more