› 4mvd

X-ray diffraction
8Å resolution

Function and Biology Details

Reaction catalysed: 
CTP + phosphocholine = diphosphate + CDP-choline
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148763 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Choline-phosphate cytidylyltransferase A Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 332 amino acids
Theoretical weight: 38.06 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P19836 (Residues: 1-312; Coverage: 85%)
Gene names: Ctpct, Pcyt1, Pcyt1a
Sequence domains: Cytidylyltransferase-like

Ligands and Environments

1 bound ligand:
Ligand CDC 8 x CDC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P43
Unit cell:
a: 107.78Å b: 107.78Å c: 575.71Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.38 0.379 0.407
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

7 review citations

Lipid landscapes and pipelines in membrane homeostasis.
Holthuis et al. (2014)
6 more

3 mentions without citation

Genetic diseases of the Kennedy pathways for membrane synthesis.
Tavasoli et al. (2020)
2 more