› 4n1d

X-ray diffraction
1.91Å resolution

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146274 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bone morphogenetic protein 2; Nodal homolog Chain: A
Molecule details ›
Chain: A
Length: 116 amino acids
Theoretical weight: 13.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P12643 (Residues: 283-305, 362-396; Coverage: 16%)
  • Canonical: Q96S42 (Residues: 257-313; Coverage: 18%)
Gene names: BMP2, BMP2A, NODAL
Sequence domains: Transforming growth factor beta like domain
Structure domains: Cystine-knot cytokines

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: R32
Unit cell:
a: 95.57Å b: 95.57Å c: 97.494Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.178 0.175 0.204
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Structural Biology and Evolution of the TGF-β Family.
Hinck et al. (2016)
3 more

2 mentions without citation

Designer nodal/BMP2 chimeras mimic nodal signaling, promote chondrogenesis, and reveal a BMP2-like structure.
Esquivies et al. (2014)
1 more