› 4n21

X-ray diffraction
1.99Å resolution

Crystal structure of the GP2 Core Domain from the California Academy of Science Virus

Released:
DOI: 10.2210/pdb4n21/pdb
PDB entry 4n21 coloured by chain, front view.
PDB entry 4n21 coloured by chain, side view.
PDB entry 4n21 coloured by chain, top view.
Source organism: CAS virus
Primary publication:
Structural characterization of the glycoprotein GP2 core domain from the CAS virus, a novel arenavirus-like species.
Koellhoffer JF, Dai Z, Malashkevich VN, Stenglein MD, Liu Y, Toro R, S Harrison J, Chandran K, DeRisi JL, Almo SC, Lai JR
J Mol Biol 426 1452-68 (2014)
PMID: 24333483

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-125337 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycoprotein Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 130 amino acids
Theoretical weight: 15.18 KDa
Source organism: CAS virus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: J7H5L9 (Residues: 257-351; Coverage: 24%)
Gene name: GPC
Structure domains: Helix Hairpins

Ligands and Environments

1 bound ligand:
Ligand MPD 11 x MPD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P1
Unit cell:
a: 46.676Å b: 46.713Å c: 109.451Å
α: 102.32° β: 89.99° γ: 119.98°
R-values:
R R work R free
0.17 0.168 0.212
Expression system: Escherichia coli BL21(DE3)

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Citations

1 review citation

Novel drug discovery approaches for treating arenavirus infections.
Pasquato et al. (2016)
11 other articles

3 mentions without citation

Structural characterization of the glycoprotein GP2 core domain from the CAS virus, a novel arenavirus-like species.
Koellhoffer et al. (2014)
2 more