› 4n3x

X-ray diffraction
2Å resolution

Crystal structure of Rabex-5 CC domain

Released:
DOI: 10.2210/pdb4n3x/pdb
PDB entry 4n3x coloured by chain, front view.
PDB entry 4n3x coloured by chain, side view.
PDB entry 4n3x coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5.
Zhang Z, Zhang T, Wang S, Gong Z, Tang C, Chen J, Ding J
Elife 3 (2014)
PMID: 24957337

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193801 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Rab5 GDP/GTP exchange factor Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 51 amino acids
Theoretical weight: 6.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UJ41 (Residues: 409-455; Coverage: 10%)
Gene names: RABEX5, RABGEF1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P21
Unit cell:
a: 46.757Å b: 40.345Å c: 51.591Å
α: 90° β: 95.14° γ: 90°
R-values:
R R work R free
0.193 0.191 0.234
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Molecular control of Rab activity by GEFs, GAPs and GDI.
Müller et al. (2018)
6 more

1 mention without citation

Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5.
Zhang et al. (2014)