› 4n40

X-ray diffraction
3.11Å resolution

Crystal structure of human Epithelial cell-transforming sequence 2 protein

Released:
DOI: 10.2210/pdb4n40/pdb
PDB entry 4n40 coloured by chain, front view.
PDB entry 4n40 coloured by chain, side view.
PDB entry 4n40 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of triple-BRCT-domain of ECT2 and insights into the binding characteristics to CYK-4.
Zou Y, Shao Z, Peng J, Li F, Gong D, Wang C, Zuo X, Zhang Z, Wu J, Shi Y, Gong Q
FEBS Lett 588 2911-20 (2014)
PMID: 25068414

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo trimer
Assembly name:
PDBe Complex ID:
PDB-CPX-190684 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein ECT2 Chain: A
Molecule details ›
Chain: A
Length: 281 amino acids
Theoretical weight: 33.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H8V3 (Residues: 45-356; Coverage: 31%)
Gene name: ECT2
Sequence domains:
Structure domains: BRCT domain

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 11 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: R3
Unit cell:
a: 123.7Å b: 123.7Å c: 89.244Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.217 0.214 0.281
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Centralspindlin in Rappaport's cleavage signaling.
Mishima M. (2016)
8 other articles

6 mentions without citation

Plasma Membrane Association but Not Midzone Recruitment of RhoGEF ECT2 Is Essential for Cytokinesis.
Kotýnková et al. (2016)
5 more