Function and Biology Details
Reaction catalysed:
S-adenosyl-L-methionine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-[mRNA]
Biochemical function:
Biological process:
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185358 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Molecule details ›
Chains: A, B
Length: 428 amino acids
Theoretical weight: 48.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: FtsJ-like methyltransferase
Structure domains: Rossmann fold
Length: 428 amino acids
Theoretical weight: 48.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
Q8N1G2 (Residues: 126-550; Coverage: 51%)
Sequence domains: FtsJ-like methyltransferase
Structure domains: Rossmann fold
