› 4n5t

X-ray diffraction
1.7Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-164858 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein Mdm4 Chain: A
Molecule details ›
Chain: A
Length: 90 amino acids
Theoretical weight: 10.32 KDa
Source organism: Danio rerio
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q7ZUW7 (Residues: 17-106; Coverage: 18%)
Gene names: mdm4, mdmx
Sequence domains: SWIB/MDM2 domain
Structure domains: SWIB/MDM2 domain
ATSP-7041 stapled-peptide Chain: B
Molecule details ›
Chain: B
Length: 15 amino acids
Theoretical weight: 1.73 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MK8 1 x MK8

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2221
Unit cell:
a: 81.585Å b: 108.535Å c: 30.964Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.209 0.228
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

109 review citations

Drugging the undruggable RAS: Mission possible?
Cox et al. (2014)
108 more

12 mentions without citation

Stapled Peptides Inhibitors: A New Window for Target Drug Discovery.
Ali et al. (2019)
11 more