› 4n70

X-ray diffraction
2.1Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145753 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase pim-1 Chain: A
Molecule details ›
Chain: A
Length: 328 amino acids
Theoretical weight: 37.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P11309 (Residues: 2-313; Coverage: 100%)
Gene name: PIM1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 2HX 1 x 2HX
1 modified residue:
Ligand SEP 1 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P65
Unit cell:
a: 97.95Å b: 97.95Å c: 81.08Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.169 0.167 0.208
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

Targeting the Pim kinases in multiple myeloma.
Keane et al. (2015)
3 more

2 mentions without citation

Five Years of the KNIME Vernalis Cheminformatics Community Contribution.
Roughley SD. (2020)
1 more