› 4nb5

X-ray diffraction
1.64Å resolution

Crystal Structure of a transcriptional regulator

Released:
DOI: 10.2210/pdb4nb5/pdb
PDB entry 4nb5 coloured by chain, front view.
PDB entry 4nb5 coloured by chain, side view.
PDB entry 4nb5 coloured by chain, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Primary publication:
Crystal structure of the transcriptional regulator Rv0678 of Mycobacterium tuberculosis.
Radhakrishnan A, Kumar N, Wright CC, Chou TH, Tringides ML, Bolla JR, Lei HT, Rajashankar KR, Su CC, Purdy GE, Yu EW
J Biol Chem 289 16526-40 (2014)
PMID: 24737322

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-125200 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HTH-type transcriptional regulator MmpR5 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 171 amino acids
Theoretical weight: 19.2 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli
UniProt:
  • Canonical: I6Y8F7 (Residues: 2-165; Coverage: 99%)
Gene names: P425_00707, RVBD_0678, Rv0678, mmpR5
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 2JT 2 x 2JT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P1
Unit cell:
a: 54.539Å b: 57.245Å c: 61.441Å
α: 82.24° β: 68.4° γ: 72.2°
R-values:
R R work R free
0.167 0.166 0.19
Expression system: Escherichia coli

Quick links

Citations

7 review citations

The diverse family of MmpL transporters in mycobacteria: from regulation to antimicrobial developments.
Viljoen et al. (2017)
6 more

8 mentions without citation

Crystal structure of the transcriptional regulator Rv0678 of Mycobacterium tuberculosis.
Radhakrishnan et al. (2014)
7 more