› 4nfm

X-ray diffraction
2.12Å resolution

Human tau tubulin kinase 1 (TTBK1)

Released:
DOI: 10.2210/pdb4nfm/pdb
PDB entry 4nfm coloured by chain, front view.
PDB entry 4nfm coloured by chain, side view.
PDB entry 4nfm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitor.
Kiefer SE, Chang CJ, Kimura SR, Gao M, Xie D, Zhang Y, Zhang G, Gill MB, Mastalerz H, Thompson LA, Cacace AM, Sheriff S
Acta Crystallogr F Struct Biol Commun 70 173-81 (2014)
PMID: 24637750

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178328 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tau-tubulin kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 332 amino acids
Theoretical weight: 37.88 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q5TCY1 (Residues: 14-343; Coverage: 25%)
Gene names: BDTK, KIAA1855, TTBK1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: C2
Unit cell:
a: 170.3Å b: 39.9Å c: 50.4Å
α: 90° β: 104.3° γ: 90°
R-values:
R R work R free
0.206 0.204 0.241
Expression system: Spodoptera frugiperda

Quick links

Citations

4 review citations

Tau-tubulin kinase.
Ikezu et al. (2014)
3 more

2 mentions without citation

The structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitor.
Kiefer et al. (2014)
1 more