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› 4nl0

X-ray diffraction
2.41Å resolution

Structural and functional characterization of a novel Alpha Kinase in complex with ADP from Entamoeba histolytica

Released:
DOI: 10.2210/pdb4nl0/pdb
Model geometry
Fit model/data
PDB entry 4nl0 coloured by chain, front view.
PDB entry 4nl0 coloured by chain, side view.
PDB entry 4nl0 coloured by chain, top view.
Source organism: Entamoeba histolytica HM-1:IMSS-B
Entry authors: Tarique KF, Rehman SAA, Bhattacharya A, Gourinath S, Mansuri MS

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-125981 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein kinase, putative Chains: A, B
Molecule details ›
Chains: A, B
Length: 288 amino acids
Theoretical weight: 33.52 KDa
Source organism: Entamoeba histolytica HM-1:IMSS-B
Expression system: Escherichia coli
UniProt:
  • Canonical: M3TP73 (Residues: 1-280; Coverage: 64%)
Gene name: EHI8A_073090
Sequence domains: Alpha-kinase family
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand ZN 2 x ZN
Ligand ADP 1 x ADP
1 modified residue:
Ligand TPO 4 x TPO

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P212121
Unit cell:
a: 51.5Å b: 90.03Å c: 123.72Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.206 0.236
Expression system: Escherichia coli

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