› 4nm4

X-ray diffraction
2.65Å resolution

Crystal structure of broadly neutralizing antibody CR8043

Released:
DOI: 10.2210/pdb4nm4/pdb
PDB entry 4nm4 coloured by chain, front view.
PDB entry 4nm4 coloured by chain, side view.
PDB entry 4nm4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A common solution to group 2 influenza virus neutralization.
Friesen RH, Lee PS, Stoop EJ, Hoffman RM, Ekiert DC, Bhabha G, Yu W, Juraszek J, Koudstaal W, Jongeneelen M, Korse HJ, Ophorst C, Brinkman-van der Linden EC, Throsby M, Kwakkenbos MJ, Bakker AQ, Beaumont T, Spits H, Kwaks T, Vogels R, Ward AB, Goudsmit J, Wilson IA
Proc Natl Acad Sci U S A 111 445-50 (2014)
PMID: 24335589

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134637 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Immunoglobulin kappa constant Chains: L, M
Molecule details ›
Chains: L, M
Length: 220 amino acids
Theoretical weight: 24.23 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01834 (Residues: 1-107; Coverage: 100%)
Gene name: IGKC
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Ig-like domain-containing protein Chains: H, I
Molecule details ›
Chains: H, I
Length: 224 amino acids
Theoretical weight: 23.92 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: S6C4S0 (Residues: 20-245; Coverage: 88%)
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand PEG 3 x PEG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P1
Unit cell:
a: 59.954Å b: 68.634Å c: 72.401Å
α: 78.67° β: 78.93° γ: 86.18°
R-values:
R R work R free
0.178 0.175 0.232

Quick links

Citations

49 review citations

Advances in the development of influenza virus vaccines.
Krammer et al. (2015)
48 more

7 mentions without citation

Tackling influenza with broadly neutralizing antibodies.
Corti et al. (2017)
6 more