› 4nn0

X-ray diffraction
1.42Å resolution

Crystal structure of the C1QTNF5 globular domain in space group P63

Released:
DOI: 10.2210/pdb4nn0/pdb
PDB entry 4nn0 coloured by chain, front view.
PDB entry 4nn0 coloured by chain, side view.
PDB entry 4nn0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The macular degeneration-linked C1QTNF5 (S163) mutation causes higher-order structural rearrangements.
Tu X, Palczewski K
J Struct Biol 186 86-94 (2014)
PMID: 24531000

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189789 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Complement C1q tumor necrosis factor-related protein 5 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 148 amino acids
Theoretical weight: 16.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BXJ0 (Residues: 103-243; Coverage: 62%)
Gene names: C1QTNF5, CTRP5, UNQ303/PRO344
Sequence domains: C1q domain
Structure domains: Jelly Rolls

Ligands and Environments

3 bound ligands:
Ligand EDO 18 x EDO
Ligand SO4 3 x SO4
Ligand ACT 2 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P63
Unit cell:
a: 50.603Å b: 50.603Å c: 268.531Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.106 0.104 0.142
Expression system: Escherichia coli

Quick links

Citations

2 review citations

RXFP1 is Targeted by Complement C1q Tumor Necrosis Factor-Related Factor 8 in Brain Cancer.
Thanasupawat et al. (2015)
1 more

3 mentions without citation

Novel pathogenic mutations in C1QTNF5 support a dominant negative disease mechanism in late-onset retinal degeneration.
Stanton et al. (2017)
2 more