› 4nng

X-ray diffraction
2.02Å resolution

Structural basis for targeting the ribosomal protein S1 of Mycobacterium tuberculosis by pyrazinamide

Released:
DOI: 10.2210/pdb4nng/pdb
PDB entry 4nng coloured by chain, front view.
PDB entry 4nng coloured by chain, side view.
PDB entry 4nng coloured by chain, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Primary publication:
Structural basis for targeting the ribosomal protein S1 of Mycobacterium tuberculosis by pyrazinamide.
Yang J, Liu Y, Bi J, Cai Q, Liao X, Li W, Guo C, Zhang Q, Lin T, Zhao Y, Wang H, Liu J, Zhang X, Lin D
Mol Microbiol 95 791-803 (2015)
PMID: 25430994

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161541 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Small ribosomal subunit protein bS1 Chain: A
Molecule details ›
Chain: A
Length: 158 amino acids
Theoretical weight: 18.34 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WH43 (Residues: 285-435; Coverage: 31%)
Gene names: MTCY01B2.22, Rv1630, rpsA
Sequence domains: S1 RNA binding domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 52.133Å b: 56.031Å c: 65.342Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.207 0.26
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Antibiotic resistance mechanisms in M. tuberculosis: an update.
Nguyen L. (2016)
7 more