› 4nqn

X-ray diffraction
1.73Å resolution

Crystal Structure of the bromodomain of human BRD9 in complex with a triazolo-phthalazine ligand

Released:
DOI: 10.2210/pdb4nqn/pdb
PDB entry 4nqn coloured by chain, front view.
PDB entry 4nqn coloured by chain, side view.
PDB entry 4nqn coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Filippakopoulos P, Picaud S, Felletar I, Martin S, Fedorov O, von Delft F, Arrowsmith CH, Edwards AM, Bountra C, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190676 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 9 Chain: A
Molecule details ›
Chain: A
Length: 123 amino acids
Theoretical weight: 14.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9H8M2 (Residues: 134-243; Coverage: 18%)
Gene names: BRD9, UNQ3040/PRO9856
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

1 bound ligand:
Ligand Y1Z 1 x Y1Z
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P212121
Unit cell:
a: 47.12Å b: 48.42Å c: 69.32Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.188 0.245
Expression system: Escherichia coli BL21(DE3)

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