› 4ns5

X-ray diffraction
1.9Å resolution

Crystal structure of human BS69 Bromo-Zinc finger-PWWP

Released:
DOI: 10.2210/pdb4ns5/pdb
PDB entry 4ns5 coloured by chain, front view.
PDB entry 4ns5 coloured by chain, side view.
PDB entry 4ns5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human BS69 Bromo-ZnF-PWWP reveals its role in H3K36me3 nucleosome binding.
Wang J, Qin S, Li F, Li S, Zhang W, Peng J, Zhang Z, Gong Q, Wu J, Shi Y
Cell Res 24 890-3 (2014)
PMID: 24675531

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172259 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Zinc finger MYND domain-containing protein 11 Chain: A
Molecule details ›
Chain: A
Length: 227 amino acids
Theoretical weight: 27.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15326 (Residues: 154-371; Coverage: 36%)
Gene names: BRAM1, BS69, ZMYND11
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P212121
Unit cell:
a: 54.76Å b: 64.38Å c: 73.4Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.206 0.251
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Lysine Acetylation Goes Global: From Epigenetics to Metabolism and Therapeutics.
Ali et al. (2018)
6 more

3 mentions without citation

PWWP domains and their modes of sensing DNA and histone methylated lysines.
Rona et al. (2016)
2 more