› 4nsc

X-ray diffraction
3.2Å resolution

Crystal Structure of CBARA1 in the Apo-form

Released:
DOI: 10.2210/pdb4nsc/pdb
PDB entry 4nsc coloured by chain, front view.
PDB entry 4nsc coloured by chain, side view.
PDB entry 4nsc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptake.
Wang L, Yang X, Li S, Wang Z, Liu Y, Feng J, Zhu Y, Shen Y
EMBO J 33 594-604 (2014)
PMID: 24514027

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189656 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium uptake protein 1, mitochondrial Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 401 amino acids
Theoretical weight: 46.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BPX6 (Residues: 97-476; Coverage: 80%)
Gene names: CALC, CBARA1, MICU1
Sequence domains: EF hand

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P21
Unit cell:
a: 90.879Å b: 146.819Å c: 115.872Å
α: 90° β: 111.08° γ: 90°
R-values:
R R work R free
0.259 0.254 0.307
Expression system: Escherichia coli

Quick links

Citations

28 review citations

Calcium at the Center of Cell Signaling: Interplay between Endoplasmic Reticulum, Mitochondria, and Lysosomes.
Raffaello et al. (2016)
27 more

12 mentions without citation

Mitochondrial Ca2+ transport in the endothelium: regulation by ions, redox signalling and mechanical forces.
Alevriadou et al. (2017)
11 more