› 4ntf

X-ray diffraction
2.65Å resolution

Mus Musculus LTC4 synthase in S-hexyl-GSH complex form

Released:
DOI: 10.2210/pdb4ntf/pdb
PDB entry 4ntf coloured by chain, front view.
PDB entry 4ntf coloured by chain, side view.
PDB entry 4ntf coloured by chain, top view.
Source organism: Mus musculus
Entry authors: Niegowski D, Rinaldo-Matthis A, Haeggstrom JZ

Function and Biology Details

Reaction catalysed: 
Leukotriene C(4) = leukotriene A(4) + glutathione
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178826 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Leukotriene C4 synthase Chain: A
Molecule details ›
Chain: A
Length: 156 amino acids
Theoretical weight: 17.66 KDa
Source organism: Mus musculus
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q60860 (Residues: 2-150; Coverage: 99%)
Gene name: Ltc4s
Sequence domains: MAPEG family
Structure domains: Membrane associated eicosanoid/glutathione metabolism-like domain

Ligands and Environments


Cofactor: Ligand GTX 1 x GTX
3 bound ligands:
Ligand PLM 4 x PLM
Ligand SO4 1 x SO4
Ligand NI 1 x NI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: F23
Unit cell:
a: 169.107Å b: 169.107Å c: 169.107Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.216 0.245
Expression system: Komagataella pastoris

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