› 4nup

X-ray diffraction
2.7Å resolution

Crystal structure of mouse N-cadherin EC1-2 with AA insertion between residues 2 and 3

Released:
DOI: 10.2210/pdb4nup/pdb
PDB entry 4nup coloured by chain, front view.
PDB entry 4nup coloured by chain, side view.
PDB entry 4nup coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural and energetic determinants of adhesive binding specificity in type I cadherins.
Vendome J, Felsovalyi K, Song H, Yang Z, Jin X, Brasch J, Harrison OJ, Ahlsen G, Bahna F, Kaczynska A, Katsamba PS, Edmond D, Hubbell WL, Shapiro L, Honig B
Proc Natl Acad Sci U S A 111 E4175-84 (2014)
PMID: 25253890

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147223 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cadherin-2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 217 amino acids
Theoretical weight: 23.76 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P15116 (Residues: 160-161, 162-374; Coverage: 24%)
Gene name: Cdh2
Sequence domains: Cadherin domain
Structure domains: Cadherins

Ligands and Environments

1 bound ligand:
Ligand CA 10 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4C
Spacegroup: P21212
Unit cell:
a: 175.504Å b: 65.791Å c: 102.505Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.175 0.172 0.229
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Adhesion Protein Structure, Molecular Affinities, and Principles of Cell-Cell Recognition.
Honig et al. (2020)
8 more

1 mention without citation

Structural and energetic determinants of adhesive binding specificity in type I cadherins.
Vendome et al. (2014)