› 4nuu

X-ray diffraction
1.95Å resolution

Heterotrimer structure of Region II from Plasmodium vivax Duffy Binding Protein (PvDBP) bound to the ectodomain of the Duffy Antigen Receptor for Chemokines (DARC)

Released:
DOI: 10.2210/pdb4nuu/pdb
PDB entry 4nuu coloured by chain, front view.
PDB entry 4nuu coloured by chain, side view.
PDB entry 4nuu coloured by chain, top view.
Source organisms:
Primary publication:
Red blood cell invasion by Plasmodium vivax: structural basis for DBP engagement of DARC.
Batchelor JD, Malpede BM, Omattage NS, DeKoster GT, Henzler-Wildman KA, Tolia NH
PLoS Pathog 10 e1003869 (2014)
PMID: 24415938

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
monomeric
Assembly name:
PDBe Complex ID:
PDB-CPX-149571 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Duffy receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 317 amino acids
Theoretical weight: 37.61 KDa
Source organism: Plasmodium vivax Sal-1
Expression system: Escherichia coli
UniProt:
  • Canonical: P22290 (Residues: 211-525; Coverage: 30%)
Gene name: PVDR
Sequence domains: Duffy binding domain
Structure domains:
Atypical chemokine receptor 1 Chain: C
Molecule details ›
Chain: C
Length: 32 amino acids
Theoretical weight: 3.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16570 (Residues: 14-43; Coverage: 9%)
Gene names: ACKR1, DARC, FY, GPD

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P21
Unit cell:
a: 59.59Å b: 66.99Å c: 97.92Å
α: 90° β: 102.11° γ: 90°
R-values:
R R work R free
0.166 0.165 0.202
Expression system: Escherichia coli

Quick links

Citations

16 review citations

A guide to chemokines and their receptors.
Hughes et al. (2018)
15 more

14 mentions without citation

The apicomplexan glideosome and adhesins - Structures and function.
Boucher et al. (2015)
13 more