› 4nxt

X-ray diffraction
2.12Å resolution

Crystal structure of the cytosolic domain of human MiD51

Released:
DOI: 10.2210/pdb4nxt/pdb
PDB entry 4nxt coloured by chain, front view.
PDB entry 4nxt coloured by chain, side view.
PDB entry 4nxt coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and functional analysis of MiD51, a dynamin receptor required for mitochondrial fission.
Richter V, Palmer CS, Osellame LD, Singh AP, Elgass K, Stroud DA, Sesaki H, Kvansakul M, Ryan MT
J Cell Biol 204 477-86 (2014)
PMID: 24515348

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192505 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitochondrial dynamics protein MIEF1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 347 amino acids
Theoretical weight: 38.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NQG6 (Residues: 119-463; Coverage: 75%)
Gene names: MID51, MIEF1, SMCR7L
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand GOL 10 x GOL
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P1
Unit cell:
a: 72.72Å b: 78.735Å c: 79.362Å
α: 66.26° β: 84.93° γ: 64.07°
R-values:
R R work R free
0.223 0.223 0.263
Expression system: Escherichia coli BL21(DE3)

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Citations

33 review citations

Metabolic regulation of mitochondrial dynamics.
Mishra et al. (2016)
32 more

5 mentions without citation

Mitochondrial quality control in the brain: The physiological and pathological roles.
Shen et al. (2022)
4 more