› 4oce

X-ray diffraction
1.77Å resolution

Crystal structure of the disulfide oxidoreductase DsbA from Proteus mirabilis

Released:
DOI: 10.2210/pdb4oce/pdb
PDB entry 4oce coloured by chain, front view.
PDB entry 4oce coloured by chain, side view.
PDB entry 4oce coloured by chain, top view.
Source organism: Proteus mirabilis HI4320
Primary publication:
Crystal structure of the dithiol oxidase DsbA enzyme from proteus mirabilis bound non-covalently to an active site peptide ligand.
Kurth F, Duprez W, Premkumar L, Schembri MA, Fairlie DP, Martin JL
J Biol Chem 289 19810-22 (2014)
PMID: 24831013

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-110077 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thiol:disulfide interchange protein Chain: A
Molecule details ›
Chain: A
Length: 190 amino acids
Theoretical weight: 21.03 KDa
Source organism: Proteus mirabilis HI4320
Expression system: Escherichia coli
UniProt:
  • Canonical: B4EZ68 (Residues: 18-207; Coverage: 100%)
Gene names: PMI2828, dsbA
Sequence domains: DSBA-like thioredoxin domain
Structure domains: Glutaredoxin

Ligands and Environments

1 bound ligand:
Ligand MLI 1 x MLI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P43212
Unit cell:
a: 37.83Å b: 37.83Å c: 298.45Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.149 0.148 0.169
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Targeting Bacterial Dsb Proteins for the Development of Anti-Virulence Agents.
Smith et al. (2016)
4 more

1 mention without citation

Crystal structure of the dithiol oxidase DsbA enzyme from proteus mirabilis bound non-covalently to an active site peptide ligand.
Kurth et al. (2014)