› 4od5

X-ray diffraction
3.56Å resolution

Substrate-bound structure of a UbiA homolog from Aeropyrum pernix K1

Released:
DOI: 10.2210/pdb4od5/pdb
PDB entry 4od5 coloured by chain, front view.
PDB entry 4od5 coloured by chain, side view.
PDB entry 4od5 coloured by chain, top view.
Source organism: Aeropyrum pernix K1
Primary publication:
Structural insights into ubiquinone biosynthesis in membranes.
Cheng W, Li W
Science 343 878-81 (2014)
PMID: 24558159

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195454 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
4-hydroxybenzoate octaprenyltransferase Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 303 amino acids
Theoretical weight: 31.84 KDa
Source organism: Aeropyrum pernix K1
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9YBM8 (Residues: 1-284; Coverage: 100%)
Gene names: APE_1570, ubiA
Sequence domains: UbiA prenyltransferase family
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand GST 6 x GST
Ligand PHB 6 x PHB
Ligand MG 12 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P212121
Unit cell:
a: 70.104Å b: 122.829Å c: 423.416Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.28 0.279 0.301
Expression system: Escherichia coli

Quick links

Citations

15 review citations

Structural and Chemical Biology of Terpenoid Cyclases.
Christianson DW. (2017)
14 more

13 mentions without citation

Bringing Bioactive Compounds into Membranes: The UbiA Superfamily of Intramembrane Aromatic Prenyltransferases.
Li W. (2016)
12 more