› 4om4

X-ray diffraction
2.74Å resolution

Crystal structure of CTX A2 from Taiwan Cobra (Naja naja atra)

Released:
DOI: 10.2210/pdb4om4/pdb
PDB entry 4om4 coloured by chain, front view.
PDB entry 4om4 coloured by chain, side view.
PDB entry 4om4 coloured by chain, top view.
Source organism: Naja atra
Primary publication:
Endocytotic routes of cobra cardiotoxins depend on spatial distribution of positively charged and hydrophobic domains to target distinct types of sulfated glycoconjugates on cell surface.
Lee SC, Lin CC, Wang CH, Wu PL, Huang HW, Chang CI, Wu WG
J Biol Chem 289 20170-81 (2014)
PMID: 24898246

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134314 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytotoxin 2 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 60 amino acids
Theoretical weight: 6.76 KDa
Source organism: Naja atra
UniProt:
  • Canonical: P01442 (Residues: 22-81; Coverage: 100%)
Structure domains: CD59

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13B1
Spacegroup: P43212
Unit cell:
a: 107.412Å b: 107.412Å c: 100.256Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.197 0.26

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Citations

2 review citations

An Emergent Role for Mitochondrial Bioenergetics in the Action of Snake Venom Toxins on Cancer Cells.
Urra et al. (2022)
1 more

5 mentions without citation

Predicted structural mimicry of spike receptor-binding motifs from highly pathogenic human coronaviruses.
Beaudoin et al. (2021)
4 more