› 4om5

X-ray diffraction
2.55Å resolution

Crystal structure of CTX A4 from Taiwan Cobra (Naja naja atra)

Released:
DOI: 10.2210/pdb4om5/pdb
PDB entry 4om5 coloured by chain, front view.
PDB entry 4om5 coloured by chain, side view.
PDB entry 4om5 coloured by chain, top view.
Source organism: Naja atra
Primary publication:
Endocytotic routes of cobra cardiotoxins depend on spatial distribution of positively charged and hydrophobic domains to target distinct types of sulfated glycoconjugates on cell surface.
Lee SC, Lin CC, Wang CH, Wu PL, Huang HW, Chang CI, Wu WG
J Biol Chem 289 20170-81 (2014)
PMID: 24898246

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134316 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytotoxin 4 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 60 amino acids
Theoretical weight: 6.8 KDa
Source organism: Naja atra
UniProt:
  • Canonical: P01443 (Residues: 22-81; Coverage: 100%)
Structure domains: CD59

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL26B2
Spacegroup: P6522
Unit cell:
a: 72.933Å b: 72.933Å c: 249.422Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.217 0.215 0.262

Quick links

Citations

2 review citations

An Emergent Role for Mitochondrial Bioenergetics in the Action of Snake Venom Toxins on Cancer Cells.
Urra et al. (2022)
1 more

5 mentions without citation

Naja naja oxiana Cobra Venom Cytotoxins CTI and CTII Disrupt Mitochondrial Membrane Integrity: Implications for Basic Three-Fingered Cytotoxins.
Gasanov et al. (2015)
4 more