› 4oo6

X-ray diffraction
2.7Å resolution

Crystal structure of human KAP-beta2 bound to the NLS of HCC1 (Hepato Cellular Carcinoma protein 1)

Released:
DOI: 10.2210/pdb4oo6/pdb
PDB entry 4oo6 coloured by chain, front view.
PDB entry 4oo6 coloured by chain, side view.
PDB entry 4oo6 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Sampathkumar P, Brower A, Soniat M, Bonanno J, Hillerich B, Seidel RD, Rout MP, Chook YM, Almo SC, New York Structural Genomics Research Consortium (NYSGRC), Nucleocytoplasmic Transport: a Target for Cellular Control (NPCXstals)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172017 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transportin-1 Chain: A
Molecule details ›
Chain: A
Length: 854 amino acids
Theoretical weight: 96.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q92973 (Residues: 9-331, 375-898; Coverage: 94%)
Gene names: KPNB2, MIP1, TNPO1, TRN
Sequence domains:
Structure domains: Leucine-rich Repeat Variant
RNA-binding protein 39 Chain: B
Molecule details ›
Chain: B
Length: 27 amino acids
Theoretical weight: 3.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q14498 (Residues: 73-99; Coverage: 5%)
Gene names: HCC1, RBM39, RNPC2

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P21212
Unit cell:
a: 126.584Å b: 162.152Å c: 68.501Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.189 0.238
Expression system: Escherichia coli BL21(DE3)

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