› 4oqo

X-ray diffraction
2.42Å resolution

Crystal structure of the tryptic generated iron-free C-lobe of bovine Lactoferrin at 2.42 Angstrom resolution

Released:
DOI: 10.2210/pdb4oqo/pdb
PDB entry 4oqo coloured by chain, front view.
PDB entry 4oqo coloured by chain, side view.
PDB entry 4oqo coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Structure of the iron-free true C-terminal half of bovine lactoferrin produced by tryptic digestion and its functional significance in the gut.
Rastogi N, Singh A, Pandey SN, Sinha M, Bhushan A, Kaur P, Sharma S, Singh TP
FEBS J 281 2871-82 (2014)
PMID: 24798798

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150260 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Lactotransferrin Chains: A, B
Molecule details ›
Chains: A, B
Length: 348 amino acids
Theoretical weight: 38.03 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P24627 (Residues: 361-708; Coverage: 51%)
Gene name: LTF
Sequence domains: Transferrin
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 3 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P21
Unit cell:
a: 75.81Å b: 49.44Å c: 97.86Å
α: 90° β: 94.33° γ: 90°
R-values:
R R work R free
0.225 0.223 0.26

Quick links

Citations

2 review citations

A role for whey-derived lactoferrin and immunoglobulins in the attenuation of obesity-related inflammation and disease.
Brimelow et al. (2017)
1 more

1 mention without citation

Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA) Guidelines update - III - Cow's milk allergens and mechanisms triggering immune activation.
Jensen et al. (2022)