› 4oul

X-ray diffraction
1.95Å resolution

Crystal structure of human Caprin-2 C1q domain

Released:
DOI: 10.2210/pdb4oul/pdb
PDB entry 4oul coloured by chain, front view.
PDB entry 4oul coloured by chain, side view.
PDB entry 4oul coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into the C1q domain of Caprin-2 in canonical Wnt signaling.
Miao H, Jia Y, Xie S, Wang X, Zhao J, Chu Y, Zhou Z, Shi Z, Song X, Li L
J Biol Chem 289 34104-13 (2014)
PMID: 25331957

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179761 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Caprin-2 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 140 amino acids
Theoretical weight: 15.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6IMN6 (Residues: 996-1127; Coverage: 12%)
Gene names: C1QDC1, CAPRIN2, EEG1, KIAA1873, RNG140
Sequence domains: C1q domain
Structure domains: Jelly Rolls

Ligands and Environments

2 bound ligands:
Ligand CA 4 x CA
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P1
Unit cell:
a: 48.353Å b: 48.342Å c: 80.884Å
α: 89.51° β: 87.24° γ: 71.74°
R-values:
R R work R free
0.206 0.203 0.251
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Invertebrate C1q Domain-Containing Proteins: Molecular Structure, Functional Properties and Biomedical Potential.
Grinchenko et al. (2023)
13 other articles

1 mention without citation

Structural insights into the C1q domain of Caprin-2 in canonical Wnt signaling.
Miao et al. (2014)