› 4oum

X-ray diffraction
1.49Å resolution

Crystal structure of human Caprin-2 C1q domain

Released:
DOI: 10.2210/pdb4oum/pdb
PDB entry 4oum coloured by chain, front view.
PDB entry 4oum coloured by chain, side view.
PDB entry 4oum coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into the C1q domain of Caprin-2 in canonical Wnt signaling.
Miao H, Jia Y, Xie S, Wang X, Zhao J, Chu Y, Zhou Z, Shi Z, Song X, Li L
J Biol Chem 289 34104-13 (2014)
PMID: 25331957

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179761 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Caprin-2 Chain: A
Molecule details ›
Chain: A
Length: 140 amino acids
Theoretical weight: 15.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6IMN6 (Residues: 996-1127; Coverage: 12%)
Gene names: C1QDC1, CAPRIN2, EEG1, KIAA1873, RNG140
Sequence domains: C1q domain
Structure domains: Jelly Rolls

Ligands and Environments

3 bound ligands:
Ligand PG4 1 x PG4
Ligand FLC 1 x FLC
Ligand IPA 3 x IPA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: R3
Unit cell:
a: 77.499Å b: 77.499Å c: 53.451Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.189 0.186 0.216
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Invertebrate C1q Domain-Containing Proteins: Molecular Structure, Functional Properties and Biomedical Potential.
Grinchenko et al. (2023)
11 other articles

4 mentions without citation

Conformational Plasticity in the Transsynaptic Neurexin-Cerebellin-Glutamate Receptor Adhesion Complex.
Cheng et al. (2016)
3 more