› 4ova

X-ray diffraction
3Å resolution

Structure of the two tandem Tudor domains and a new identified KH0 domain from human Fragile X Mental Retardation Protein

Released:
DOI: 10.2210/pdb4ova/pdb
PDB entry 4ova coloured by chain, front view.
PDB entry 4ova coloured by chain, side view.
PDB entry 4ova coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The amino-terminal structure of human fragile X mental retardation protein obtained using precipitant-immobilized imprinted polymers.
Hu Y, Chen Z, Fu Y, He Q, Jiang L, Zheng J, Gao Y, Mei P, Chen Z, Ren X
Nat Commun 6 6634 (2015)
PMID: 25799254

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170394 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fragile X messenger ribonucleoprotein 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 209 amino acids
Theoretical weight: 24.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q06787 (Residues: 1-209; Coverage: 33%)
Gene name: FMR1
Sequence domains:
Structure domains: SH3 type barrels.

Ligands and Environments

1 bound ligand:
Ligand TRS 2 x TRS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NE3A
Spacegroup: C2
Unit cell:
a: 232.643Å b: 60.842Å c: 168.856Å
α: 90° β: 122.99° γ: 90°
R-values:
R R work R free
0.221 0.219 0.259
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Post-translational modifications of the Fragile X Mental Retardation Protein in neuronal function and dysfunction.
Prieto et al. (2020)
4 more

2 mentions without citation

Sumoylation regulates FMRP-mediated dendritic spine elimination and maturation.
Khayachi et al. (2018)
1 more