› 4ove

X-ray diffraction
2.64Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126714 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Netrin-1 Chain: A
Molecule details ›
Chain: A
Length: 437 amino acids
Theoretical weight: 48.99 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: O09118 (Residues: 23-457; Coverage: 75%)
Gene name: Ntn1
Sequence domains:
Structure domains: Galactose-binding domain-like

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
3 bound ligands:
Ligand NAG 1 x NAG
Ligand CA 1 x CA
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08B1-1, SLS BEAMLINE X06SA
Spacegroup: P3221
Unit cell:
a: 69.754Å b: 69.754Å c: 334.802Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.233 0.23 0.288
Expression system: Homo sapiens

Quick links

Citations

15 review citations

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
Galluzzi et al. (2018)
14 more

4 mentions without citation

Structural decoding of netrin-4 reveals a regulatory function towards mature basement membranes.
Reuten et al. (2016)
3 more