› 4p4n

X-ray diffraction
1.95Å resolution

Crystal Structure of Mycobacterium tuberculosis Shikimate Dehydrogenase

Released:
DOI: 10.2210/pdb4p4n/pdb
PDB entry 4p4n coloured by chain, front view.
PDB entry 4p4n coloured by chain, side view.
PDB entry 4p4n coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Entry authors: Lalgondar M, Sacchettini JC, TB Structural Genomics Consortium (TBSGC)

Function and Biology Details

Reaction catalysed: 
Shikimate + NADP(+) = 3-dehydroshikimate + NADPH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-125194 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Probable shikimate 5-dehydrogenase AroE (5-dehydroshikimate reductase) Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 277 amino acids
Theoretical weight: 28.29 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: I6Y120 (Residues: 1-269; Coverage: 100%)
Gene names: Rv2552c, aroE
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand SO4 5 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P21212
Unit cell:
a: 128.568Å b: 132.696Å c: 38.612Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.186 0.229
Expression system: Escherichia coli BL21(DE3)

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