› 4p4u

X-ray diffraction
1.9Å resolution

Nucleotide-free stalkless-MxA

Released:
DOI: 10.2210/pdb4p4u/pdb
PDB entry 4p4u coloured by chain, front view.
PDB entry 4p4u coloured by chain, side view.
PDB entry 4p4u coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Transient dimerization of human MxA promotes GTP hydrolysis, resulting in a mechanical power stroke.
Rennie ML, McKelvie SA, Bulloch EM, Kingston RL
Structure 22 1433-45 (2014)
PMID: 25295396

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149011 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interferon-induced GTP-binding protein Mx1, N-terminally processed Chain: A
Molecule details ›
Chain: A
Length: 363 amino acids
Theoretical weight: 40.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P20591 (Residues: 37-364, 632-661; Coverage: 54%)
Gene name: MX1
Sequence domains:
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

1 bound ligand:
Ligand SO4 6 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: I212121
Unit cell:
a: 46.33Å b: 77Å c: 205.95Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.21 0.259
Expression system: Escherichia coli

Quick links

Citations

13 review citations

Mx GTPases: dynamin-like antiviral machines of innate immunity.
Haller et al. (2015)
12 more

1 mention without citation

Structural analysis of tumor-related single amino acid mutations in human MxA protein.
Hu et al. (2015)