› 4p4x

X-ray diffraction
1.9Å resolution

Dodecamer formed by a macrocyclic peptide derived from beta-2-microglobulin (63-69) - (ORN)YLL(PHI)YTE(ORN)KVA(MLE)AVK

Released:
DOI: 10.2210/pdb4p4x/pdb
PDB entry 4p4x coloured by chain, front view.
PDB entry 4p4x coloured by chain, side view.
PDB entry 4p4x coloured by chain, top view.
Source organism: synthetic construct
Primary publication:
X-ray Crystallographic Structures of Oligomers of Peptides Derived from β2-Microglobulin.
Spencer RK, Kreutzer AG, Salveson PJ, Li H, Nowick JS
J Am Chem Soc 137 6304-11 (2015)
PMID: 25915729

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-164980 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CYCLIC HEXADECAPEPTIDE (ORN)YLL(PH7)YTE(ORN)KVA(MLE)AVK Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 16 amino acids
Theoretical weight: 2.03 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand SO4 8 x SO4
Ligand CL 2 x CL
3 modified residues:
Ligand ORN 24 x ORN
Ligand PHI 12 x PHI
Ligand MLE 12 x MLE

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P4122
Unit cell:
a: 61.343Å b: 61.343Å c: 113.963Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.209 0.235
Expression system: Not provided

Quick links

Citations

7 review citations

Elucidating the Structures of Amyloid Oligomers with Macrocyclic β-Hairpin Peptides: Insights into Alzheimer's Disease and Other Amyloid Diseases.
Kreutzer et al. (2018)
6 more

1 mention without citation

X-ray Crystallographic Structures of Oligomers of Peptides Derived from β2-Microglobulin.
Spencer et al. (2015)