4p7i

X-ray diffraction
2.6Å resolution

Crystal structure of the Merlin FERM/DCAF1 complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-155495 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Merlin Chains: A, B
Molecule details ›
Chains: A, B
Length: 317 amino acids
Theoretical weight: 37.25 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P46662 (Residues: 1-313; Coverage: 53%)
Gene names: Nf-2, Nf2
Sequence domains:
Structure domains:
DDB1- and CUL4-associated factor 1 Chains: C, D
Molecule details ›
Chains: C, D
Length: 67 amino acids
Theoretical weight: 7.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y4B6 (Residues: 1447-1507; Coverage: 4%)
Gene names: DCAF1, KIAA0800, RIP, VPRBP

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P3121
Unit cell:
a: 97.104Å b: 97.104Å c: 224.339Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.226 0.224 0.256
Expression system: Escherichia coli BL21(DE3)